Guillermo Trujillo was born in Horconcitos, Chiriqui, Panama. He started his studies in Panama and completed them in Madrid. In 1959 he obtained an Honorable Mention in the Biennial of São Paulo, and has continued to receive awards. Trujillo incorporated elements of native art and hieratic figures in a very contemporary style in his canvases. His compositions included political and social satires, as well as man related to nature.
